ZNF354A

Across TCGA patient cohorts, ZNF354A mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF354A-associated genes across cancer lineages are TFRC, ASNS, and Caspase-7-cleavedD198. Each is linked with ZNF354A in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF354A-to-partner and partner-to-ZNF354A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ZNF354A-low versus ZNF354A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF354A→partner) and Y-score (partner→ZNF354A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TFRC →	+0.571	+3.000	.026	.036	3	4
COAD	ASNS →	+0.793	+2.815	<.001	.036	3	3
UCEC	Caspase-7-cleavedD198 →	+0.575	+1.926	.006	.008	3	3
COAD	HSP70 →	+0.862	+2.820	.005	.035	3	2
COAD	Rab11 →	+0.197	+2.832	.026	.035	3	2
UCEC	GAPDH →	+0.386	+2.459	.042	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

TFRC by ZNF354A expression — BLCA

Explore this box plot interactively →