ZNF354A

Across TCGA cell cohorts, ZNF354A mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF354A-associated genes across cancer lineages are RCVRN, IL22, and CTXN2. Each is linked with ZNF354A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF354A-to-partner and partner-to-ZNF354A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCVRN grouped by ZNF354A-low versus ZNF354A-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF354A→partner) and Y-score (partner→ZNF354A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RCVRN →	+0.068	+4.807	<.001	<.001	3	1
OESOPHAGUS	IL22 →	+0.036	+4.115	<.001	.001	3	1
OESOPHAGUS	CTXN2 →	+0.023	+3.392	<.001	.007	3	1
OESOPHAGUS	PIK3R6 →	+0.051	+3.584	.002	.008	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.015	+2.933	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

RCVRN by ZNF354A expression — OESOPHAGUS

Explore this box plot interactively →