ZNF350

Across TCGA patient cohorts, ZNF350 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF350-associated genes across cancer lineages are ATM, CDK1, and p27_pT198. Each is linked with ZNF350 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF350-to-partner and partner-to-ZNF350 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF350-low versus ZNF350-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF350→partner) and Y-score (partner→ZNF350) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.451	-1.584	.005	.019	3	4
UCEC	CDK1 →	+0.172	+1.807	.001	.025	3	3
SKCM	p27_pT198 →	+0.202	+3.000	.006	.036	3	2
UCEC	eIF4E →	+0.191	+1.925	.012	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.154	-1.874	.011	.049	3	2
UCEC	P-Cadherin →	-0.182	-3.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by ZNF350 expression — UCEC

Explore this box plot interactively →