ZNF350

Across TCGA cell cohorts, ZNF350 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF350-associated genes across cancer lineages are LORICRIN, PCDH11Y, and IL31. Each is linked with ZNF350 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF350-to-partner and partner-to-ZNF350 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LORICRIN grouped by ZNF350-low versus ZNF350-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF350→partner) and Y-score (partner→ZNF350) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LORICRIN →	+0.021	+4.930	<.001	.008	3	1
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	1
SKIN	IL31 →	+0.028	+4.977	<.001	.007	3	1
BLOOD_Leukemia	PPP1R2C →	+0.321	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SPRR1A →	+0.239	+5.201	<.001	.006	3	1
LARGE_INTESTINE	SAMM50 →	+0.687	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

LORICRIN by ZNF350 expression — SOFT_TISSUE

Explore this box plot interactively →