ZNF346

Across TCGA pan-cancer cohorts, ZNF346 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF346 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNF346 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF346 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

PDAC, GBM, and LSCC are the cancer types where ZNF346 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.400	0.634	.001	81	view →
GBM	OS	Quartile	All	0.647	0.366	.015	4	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.851	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF346–PDAC (OS)

Open the PDAC breakdown →