ZNF346

Across TCGA pan-cancer cohorts, ZNF346 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZNF346’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ZNF346 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZNF346 is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

PDAC, LSCC, and HNSC are the cancer types where ZNF346 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF346 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.435	<.001	8	view →
LSCC	All	II,III,IV	+0.263	<.001	6	view →
HNSC	Female	All	−0.260	.040	3	view →
CCRCC	All	III,IV	+0.079	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZNF346–PDAC

Open the PDAC breakdown →