ZNF346

Across TCGA patient cohorts, ZNF346 mutation is significantly associated with the RNA expression of many other genes, with 2,237 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF346-associated genes across cancer lineages are RNA5SP412, HMGN2P32, and RN7SL472P. Each is linked with ZNF346 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF346-to-partner and partner-to-ZNF346 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by ZNF346-low versus ZNF346-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF346→partner) and Y-score (partner→ZNF346) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.826	+2.452	<.001	.001	3	2
UCEC	HMGN2P32 →	+0.534	+4.120	<.001	<.001	3	2
UCEC	RN7SL472P →	+0.408	+2.067	<.001	.004	3	2
COAD	RN7SKP265 →	+0.181	+5.087	<.001	.002	3	2
UCEC	PGAP2 →	+0.444	+4.010	.003	<.001	3	1
UCEC	EIF3M →	+0.461	+3.385	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,237 associations by consensus.

RNA5SP412 by ZNF346 expression — UCEC

Explore this box plot interactively →