ZNF346

Across TCGA patient cohorts, ZNF346 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF346-associated genes across cancer lineages are MEK1, eIF4G, and FoxM1. Each is linked with ZNF346 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF346-to-partner and partner-to-ZNF346 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF346-low versus ZNF346-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF346→partner) and Y-score (partner→ZNF346) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.456	+2.584	.005	.010	3	2
UCEC	eIF4G →	+0.358	+2.999	.010	.035	3	1
UCEC	FoxM1 →	+0.334	+2.700	.004	.006	3	1
UCEC	INPP4B →	-0.329	-3.321	.024	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.262	-3.459	<.001	.005	3	1
UCEC	JNK2 →	+0.234	+3.179	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MEK1 by ZNF346 expression — UCEC

Explore this box plot interactively →