ZNF346

Across TCGA cell cohorts, ZNF346 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,732 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF346-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Cell cycle checkpoint signaling, and DNA damage checkpoint signaling. Each is linked with ZNF346 in more than 17 cancer types. Because this analysis shows association rather than direction, both ZNF346-to-partner and partner-to-ZNF346 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by ZNF346-low versus ZNF346-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF346→partner) and Y-score (partner→ZNF346) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.069	+1.170	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.084	+0.996	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA damage checkpoint signaling →	+0.074	+1.079	<.001	<.001	3	17
LUNG_NSCLC_LUSC	DNA-templated transcription initiation →	+0.071	+1.167	.003	.003	2	18
STOMACH	RNA export from nucleus →	+0.113	+0.667	<.001	.003	3	17
STOMACH	Nucleocytoplasmic transport →	+0.094	+0.999	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,732 associations by consensus.

Epigenetic regulation of gene expression by ZNF346 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →