Across TCGA patient cohorts, ZNF34 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF34-associated genes across cancer lineages are MEK1, Notch1, and p62 Lck ligand. Each is linked with ZNF34 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF34-to-partner and partner-to-ZNF34 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF34→partner) and Y-score (partner→ZNF34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.429	+2.584	.007	.010	3	2
UCEC	Notch1 →	+0.231	+2.115	<.001	.019	3	2
UCEC	p62 Lck ligand →	+0.654	+3.906	<.001	<.001	3	2
UCEC	PCNA →	+0.310	+3.584	<.001	.002	3	2
UCEC	CDK1 →	+0.143	+2.183	.030	.033	3	2
UCEC	EGFR_pY1068 →	-0.220	-2.321	.045	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

ZNF34 survival (RNA) · tumor vs normal (RNA) · all ZNF34 data types