Across TCGA pan-cancer cohorts, ZNF33A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF33A data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF33A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF33A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

HNSC, UCEC, and BLCA are the cancer types where ZNF33A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.211	0.714	.001	30	view →
UCEC	OS	Median	All	0.972	0.639	.007	28	view →
BLCA	DFS	Median	IV	0.147	0.479	.026	6	view →
SKCM	DFS	Median	All	0.860	0.209	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZNF33A tumor-vs-normal RNA expression · all ZNF33A data types