ZNF337

Across TCGA patient cohorts, ZNF337 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF337-associated genes across cancer lineages are JNK2, VHL, and ATM. Each is linked with ZNF337 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF337-to-partner and partner-to-ZNF337 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ZNF337-low versus ZNF337-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF337→partner) and Y-score (partner→ZNF337) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.259	+2.070	<.001	.001	3	2
UCEC	VHL →	-0.829	-1.765	<.001	.013	3	2
UCEC	ATM →	-0.481	-2.906	.002	.001	3	2
UCEC	Chk2_pT68 →	-0.127	-1.848	.048	.049	3	2
UCEC	eIF4E →	+0.149	+1.440	.041	.024	3	1
UCEC	eIF4G →	+0.258	+2.459	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

JNK2 by ZNF337 expression — UCEC

Explore this box plot interactively →