ZNF331

Across TCGA patient cohorts, ZNF331 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF331-associated genes across cancer lineages are MEK1, Notch1, and ATM. Each is linked with ZNF331 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF331-to-partner and partner-to-ZNF331 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF331-low versus ZNF331-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF331→partner) and Y-score (partner→ZNF331) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.348	+2.584	.011	.010	3	2
UCEC	Notch1 →	+0.188	+2.713	<.001	.003	3	2
UCEC	ATM →	-0.371	-1.765	.029	.014	3	2
UCEC	ACC1 →	+0.281	+1.415	.039	.046	3	1
UCEC	Ku80 →	+0.245	+1.495	.005	.034	3	1
UCEC	MSH6 →	-0.331	-1.415	.007	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MEK1 by ZNF331 expression — UCEC

Explore this box plot interactively →