ZNF330

Across TCGA patient cohorts, ZNF330 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF330-associated genes across cancer lineages are Ku80, mTOR_pS2448, and Notch1. Each is linked with ZNF330 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF330-to-partner and partner-to-ZNF330 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ZNF330-low versus ZNF330-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF330→partner) and Y-score (partner→ZNF330) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.341	+2.472	.002	.011	3	1
UCEC	mTOR_pS2448 →	-0.174	-2.980	.015	.036	3	1
UCEC	Notch1 →	+0.290	+3.584	<.001	.002	3	1
UCEC	p62 Lck ligand →	+0.349	+3.584	.026	.002	3	1
UCEC	PDCD4 →	-0.659	-3.584	.003	.002	3	1
UCEC	Annexin-1 →	+0.633	+2.827	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by ZNF330 expression — UCEC

Explore this box plot interactively →