ZNF326

Across TCGA pan-cancer cohorts, ZNF326 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF326 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZNF326 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF326 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

LSCC, HNSC, and COAD are the cancer types where ZNF326 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.890	0.515	.001	37	view →
HNSC	DFS	Median	IV	0.667	0.942	.001	19	view →
COAD	DFS	Tertile	All	1.000	0.915	.044	6	view →
PDAC	DFS	Median	II,III,IV	0.506	0.327	.021	6	view →
LUAD	DFS	Median	II,III,IV	1.000	0.798	.015	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF326–LSCC (DFS)

Open the LSCC breakdown →