ZNF326

Across TCGA patient cohorts, ZNF326 mutation is significantly associated with the RNA expression of many other genes, with 5,000 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF326-associated genes across cancer lineages are CCL3, COX15, and SLAMF8. Each is linked with ZNF326 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF326-to-partner and partner-to-ZNF326 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL3 grouped by ZNF326-low versus ZNF326-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF326→partner) and Y-score (partner→ZNF326) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL3 →	+0.604	+2.177	.004	.001	3	3
UCEC	COX15 →	+0.561	+2.700	<.001	<.001	3	3
UCEC	SLAMF8 →	+0.736	+2.243	<.001	.005	3	3
UCEC	SMCO4 →	+0.511	+2.000	.005	.001	3	3
UCEC	CTDNEP1 →	+0.263	+3.354	.006	.005	3	3
UCEC	TYMS →	+0.830	+3.860	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,000 associations by consensus.

CCL3 by ZNF326 expression — UCEC

Explore this box plot interactively →