ZNF326

Across TCGA patient cohorts, ZNF326 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF326-associated genes across cancer lineages are eIF4E, ERK2, and Rab25. Each is linked with ZNF326 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF326-to-partner and partner-to-ZNF326 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF326-low versus ZNF326-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF326→partner) and Y-score (partner→ZNF326) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.206	+3.713	.004	<.001	3	2
UCEC	ERK2 →	+0.131	+2.000	.045	.029	3	2
UCEC	Rab25 →	-0.244	-1.247	.030	.045	3	2
UCEC	4E-BP1 →	+0.429	+4.087	<.001	<.001	3	2
COAD	C-Raf →	+0.241	+3.178	<.001	.010	3	2
COAD	p70-S6K →	+0.332	+3.195	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eIF4E by ZNF326 expression — UCEC

Explore this box plot interactively →