ZNF324B

Across TCGA pan-cancer cohorts, ZNF324B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF324B data layer compared with 11 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher ZNF324B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF324B expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

MESO, LGG, and ACC are the cancer types where ZNF324B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	III,IV	0.272	0.550	<.001	109	view →
LGG	DFS	Median	All	0.306	0.500	<.001	52	view →
ACC	DFS	Quartile	All	0.307	0.807	<.001	50	view →
HNSC	DFS	Quartile	All	0.785	0.629	.003	47	view →
KIRC	DFS	Quartile	All	0.857	0.517	<.001	43	view →
PAAD	OS	Tertile	All	0.599	0.315	.002	41	view →
LIHC	DFS	Tertile	All	0.443	0.619	<.001	38	view →
READ	OS	Median	All	1.000	0.798	.001	32	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	18	view →
SCLC	DFS	Tertile	II,III,IV	0.889	0.271	.006	13	view →
UCEC	DFS	Quartile	IV	0.666	0.197	.026	12	view →
KIRP	DFS	Quartile	III,IV	0.446	0.803	.023	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF324B–MESO (DFS)

Open the MESO breakdown →