ZNF324

Across TCGA patient cohorts, ZNF324 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF324-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and eIF4E. Each is linked with ZNF324 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF324-to-partner and partner-to-ZNF324 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF324-low versus ZNF324-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF324→partner) and Y-score (partner→ZNF324) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.362	-2.571	.033	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.819	+2.479	<.001	.010	3	2
UCEC	eIF4E →	+0.220	+2.662	.005	<.001	3	1
UCEC	ERK2 →	+0.145	+2.459	.044	.018	3	1
UCEC	Fibronectin →	-0.299	-1.765	.015	.014	3	1
UCEC	IGFBP2 →	-0.910	-2.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by ZNF324 expression — UCEC

Explore this box plot interactively →