ZNF322

Across TCGA patient cohorts, ZNF322 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF322-associated genes across cancer lineages are FoxM1, JNK2, and Notch1. Each is linked with ZNF322 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF322-to-partner and partner-to-ZNF322 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ZNF322-low versus ZNF322-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF322→partner) and Y-score (partner→ZNF322) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.312	+2.906	.004	.001	3	1
UCEC	JNK2 →	+0.235	+2.222	.005	.011	3	1
UCEC	Notch1 →	+0.225	+2.906	<.001	.001	3	1
UCEC	p27_pT198 →	+0.094	+1.700	.039	.044	3	1
UCEC	PCNA →	+0.264	+2.222	.004	.011	3	1
UCEC	PDCD4 →	-0.595	-2.312	.002	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

FoxM1 by ZNF322 expression — UCEC

Explore this box plot interactively →