ZNF32

Across TCGA patient cohorts, ZNF32 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF32-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and ERK2. Each is linked with ZNF32 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF32-to-partner and partner-to-ZNF32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF32-low versus ZNF32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF32→partner) and Y-score (partner→ZNF32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.609	+3.019	.015	.019	3	2
UCEC	14-3-3_beta →	-0.107	-3.143	.011	.018	3	1
UCEC	ERK2 →	+0.193	+2.999	.018	.035	3	1
UCEC	JNK2 →	+0.293	+3.196	<.001	.009	3	1
UCEC	MEK1 →	+0.324	+2.584	.037	.010	3	1
UCEC	MSH2 →	-0.286	-2.973	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-7-cleavedD198 by ZNF32 expression — UCEC

Explore this box plot interactively →