ZNF318

Across TCGA pan-cancer cohorts, ZNF318 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ZNF318’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZNF318 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZNF318 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where ZNF318 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF318 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.777	<.001	9	view →
LSCC	Male	All	+0.454	<.001	8	view →
HNSC	Male	II,III,IV	+0.189	<.001	8	view →
LUAD	All	II,III,IV	+0.131	<.001	6	view →
PDAC	Male	II,III,IV	−0.245	.008	4	view →
CCRCC	All	All	+0.074	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ZNF318–COAD

Open the COAD breakdown →