ZNF318

Across TCGA cell cohorts, ZNF318 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,151 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF318-associated GO terms across cancer lineages are Regulation of transcription initiation by RNA polymerase II, Negative regulation of DNA-templated transcription initiation, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with ZNF318 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF318-to-partner and partner-to-ZNF318 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription initiation by RNA polymerase II grouped by ZNF318-low versus ZNF318-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF318→partner) and Y-score (partner→ZNF318) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of transcription initiation by RNA polymerase II →	+0.080	+0.986	<.001	.001	1	15
OVARY	Negative regulation of DNA-templated transcription initiation →	+0.116	+1.049	<.001	<.001	3	13
OVARY	Negative regulation of transcription initiation by RNA polymerase II →	+0.116	+1.049	<.001	<.001	3	13
SKIN	Regulation of smoothened signaling pathway →	+0.042	+0.548	<.001	<.001	3	13
BLOOD_Lymphoma	Negative regulation of sister chromatid cohesion →	+0.114	+1.733	<.001	<.001	3	13
OVARY	Positive regulation of mitotic cytokinesis →	+0.111	+0.859	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,151 associations by consensus.

Regulation of transcription initiation by RNA polymerase II by ZNF318 expression — OESOPHAGUS

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