ZNF304

Across TCGA pan-cancer cohorts, ZNF304 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF304 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF304 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF304 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LIHC, and COAD are the cancer types where ZNF304 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.295	<.001	36	view →
LIHC	DFS	Median	All	0.035	0.545	<.001	24	view →
COAD	OS	Median	II,III,IV	0.371	0.795	.002	24	view →
SKCM	DFS	Median	III,IV	0.111	0.654	.004	10	view →
SARC	OS	Median	All	0.109	0.827	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF304–UCEC (DFS)

Open the UCEC breakdown →