ZNF304

Across TCGA patient cohorts, ZNF304 mutation is significantly associated with the RNA expression of many other genes, with 4,629 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF304-associated genes across cancer lineages are RNA5SP412, UQCRQ, and LINC02319. Each is linked with ZNF304 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF304-to-partner and partner-to-ZNF304 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by ZNF304-low versus ZNF304-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF304→partner) and Y-score (partner→ZNF304) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.360	+1.619	.001	.002	3	3
SKCM	UQCRQ →	+0.489	+3.331	.003	.005	3	3
CESC	LINC02319 →	+0.258	+3.975	<.001	.006	3	3
SCLC	KRT26 →	+0.067	+5.624	<.001	.003	3	2
UCEC	UHRF1 →	+1.126	+2.470	<.001	<.001	3	2
UCEC	PIGW →	+0.616	+2.470	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,629 associations by consensus.

RNA5SP412 by ZNF304 expression — UCEC

Explore this box plot interactively →