ZNF304

Across TCGA patient cohorts, ZNF304 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF304-associated genes across cancer lineages are ASNS, EGFR_pY1068, and A-Raf_pS299. Each is linked with ZNF304 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF304-to-partner and partner-to-ZNF304 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ZNF304-low versus ZNF304-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF304→partner) and Y-score (partner→ZNF304) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.846	+2.815	<.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.190	-1.700	.013	.001	3	2
UCEC	A-Raf_pS299 →	-0.112	-2.087	.002	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.145	-1.440	.004	.022	3	2
UCEC	p62 Lck ligand →	+0.281	+1.512	.004	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.737	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by ZNF304 expression — COAD

Explore this box plot interactively →