ZNF304

Across TCGA cell cohorts, ZNF304 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF304-associated genes across cancer lineages are CLEC18C, COL6A5, and TNK1. Each is linked with ZNF304 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF304-to-partner and partner-to-ZNF304 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC18C grouped by ZNF304-low versus ZNF304-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF304→partner) and Y-score (partner→ZNF304) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLEC18C →	+0.137	+3.240	.001	.007	3	1
LARGE_INTESTINE	COL6A5 →	+0.565	+3.987	<.001	<.001	3	1
LARGE_INTESTINE	TNK1 →	+0.776	+3.064	.008	.009	3	1
LARGE_INTESTINE	DAZ4 →	+0.109	+2.977	.008	.006	3	1
LARGE_INTESTINE	FBXO42 →	+0.731	+3.064	<.001	.009	3	1
LARGE_INTESTINE	IPCEF1 →	+0.428	+3.215	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

CLEC18C by ZNF304 expression — LARGE_INTESTINE

Explore this box plot interactively →