ZNF300

Across TCGA patient cohorts, ZNF300 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF300-associated genes across cancer lineages are ASNS, ATM, and Acetyl-a-Tubulin-Lys40. Each is linked with ZNF300 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF300-to-partner and partner-to-ZNF300 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ZNF300-low versus ZNF300-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF300→partner) and Y-score (partner→ZNF300) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.648	+3.169	.002	.018	3	2
UCEC	ATM →	-0.440	-1.986	.001	.008	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.644	+2.321	.019	.035	3	1
SKCM	PARP_cleaved →	+0.183	+3.000	.018	.034	3	1
SKCM	TAZ →	+0.192	+2.321	.015	.035	3	1
UCEC	eIF4E →	+0.190	+3.598	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ASNS by ZNF300 expression — SKCM

Explore this box plot interactively →