ZNF300

Across TCGA cell cohorts, ZNF300 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZNF300-associated genes across cancer lineages are GFRAL, APOC4, and OTOL1. Each is linked with ZNF300 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF300-to-partner and partner-to-ZNF300 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRAL grouped by ZNF300-low versus ZNF300-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF300→partner) and Y-score (partner→ZNF300) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GFRAL →	+0.006	+5.614	<.001	.002	3	2
CNS	APOC4 →	+0.144	+3.887	<.001	.001	3	2
CNS	OTOL1 →	+0.051	+3.730	<.001	.002	3	2
PANCREAS	TBX22 →	+0.083	+5.614	<.001	.002	3	1
PANCREAS	RPL10L →	+0.666	+5.000	<.001	.006	3	1
PANCREAS	OLIG3 →	+0.006	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

GFRAL by ZNF300 expression — PANCREAS

Explore this box plot interactively →