ZNF3

Across TCGA patient cohorts, ZNF3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF3-associated genes across cancer lineages are EGFR_pY1068, FASN, and FoxM1. Each is linked with ZNF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF3-to-partner and partner-to-ZNF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF3-low versus ZNF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF3→partner) and Y-score (partner→ZNF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.226	-1.847	.014	.008	3	1
UCEC	FASN →	+0.284	+1.502	.049	.030	3	1
UCEC	FoxM1 →	+0.246	+2.247	.009	.001	3	1
UCEC	ACC_pS79 →	+0.289	+1.502	.023	.030	3	1
UCEC	ACC1 →	+0.361	+3.335	.006	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.155	-1.874	.012	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by ZNF3 expression — UCEC

Explore this box plot interactively →