ZNF3

Across TCGA cell cohorts, ZNF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,042 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF3-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Regulation of double-strand break repair, and Positive regulation of double-strand break repair. Each is linked with ZNF3 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF3-to-partner and partner-to-ZNF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by ZNF3-low versus ZNF3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF3→partner) and Y-score (partner→ZNF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Pre-mRNA catabolic process →	+0.163	+0.793	<.001	<.001	3	15
SOFT_TISSUE	Regulation of double-strand break repair →	+0.099	+0.927	<.001	<.001	3	15
BONE	Positive regulation of double-strand break repair →	+0.069	+0.854	.003	.002	3	15
BONE	Positive regulation of DNA recombination →	+0.145	+1.250	<.001	.001	3	14
LUNG_NSCLC_LUSC	Negative regulation of translational initiation →	+0.101	+1.088	.003	.007	2	15
BONE	Regulation of DNA repair →	+0.100	+1.233	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,042 associations by consensus.

Pre-mRNA catabolic process by ZNF3 expression — KIDNEY

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