ZNF296

Across TCGA pan-cancer cohorts, ZNF296 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF296 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher ZNF296 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF296 expression acts as an unfavorable survival marker.

ESCA, LUSC, and SKCM are the cancer types where ZNF296 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.136	0.703	<.001	24	view →
LUSC	OS	Median	II,III,IV	0.172	0.732	.003	6	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF296–ESCA (OS)

Open the ESCA breakdown →