ZNF296

Across TCGA cell cohorts, ZNF296 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,144 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF296-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Cytoplasm protein quality control by the ubiquitin-proteasome system, and rRNA transcription. Each is linked with ZNF296 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZNF296-to-partner and partner-to-ZNF296 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by ZNF296-low versus ZNF296-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF296→partner) and Y-score (partner→ZNF296) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.152	+0.923	<.001	.001	3	9
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.134	+0.612	<.001	<.001	3	9
BONE	rRNA transcription →	+0.113	+0.681	<.001	<.001	3	8
BONE	Negative regulation of hydrogen peroxide biosynthetic process →	-0.215	-0.736	.002	.002	3	8
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	-0.240	-1.078	.008	.001	3	8
BONE	Cytoplasm protein quality control →	+0.143	+0.948	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,144 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by ZNF296 expression — OESOPHAGUS

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