ZNF296

Across TCGA cell cohorts, ZNF296 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF296-associated genes across cancer lineages are OR4C45, EDEM1, and SSMEM1. Each is linked with ZNF296 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF296-to-partner and partner-to-ZNF296 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4C45 grouped by ZNF296-low versus ZNF296-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF296→partner) and Y-score (partner→ZNF296) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR4C45 →	+0.017	+4.781	<.001	.003	3	1
LARGE_INTESTINE	EDEM1 →	+0.898	+3.067	<.001	.009	3	1
LARGE_INTESTINE	SSMEM1 →	+0.020	+2.707	.002	.003	3	1
LARGE_INTESTINE	LPAR3 →	+0.991	+3.314	.006	.005	3	1
LARGE_INTESTINE	RWDD4 →	+0.520	+3.064	.002	.009	3	1
LARGE_INTESTINE	SMIM11A →	+1.170	+3.125	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR4C45 by ZNF296 expression — BREAST

Explore this box plot interactively →