ZNF296

Across TCGA cell cohorts, ZNF296 mutation is significantly associated with the mutation status of many other genes, with 2,667 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF296-associated genes across cancer lineages are IGF1R, EIF2AK4, and SLX4. Each is linked with ZNF296 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF296-to-partner and partner-to-ZNF296 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGF1R grouped by ZNF296-low versus ZNF296-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF296→partner) and Y-score (partner→ZNF296) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IGF1R →	+3.101	+4.847	<.001	<.001	1	4
BREAST	EIF2AK4 →	+4.857	+4.297	.009	.009	1	4
BLOOD_Leukemia	SLX4 →	+2.560	+4.364	.002	.002	1	4
BLOOD_Leukemia	TRPA1 →	+3.338	+4.083	.003	.003	1	4
BREAST	AKAP11 →	+4.857	+4.297	.009	.009	1	3
BREAST	MPO →	+4.857	+4.297	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,667 associations by consensus.

IGF1R by ZNF296 expression — BLOOD_Leukemia

Explore this box plot interactively →