ZNF295-AS1

Across TCGA pan-cancer cohorts, ZNF295-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZNF295-AS1 data layer compared with 1 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher ZNF295-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF295-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CHOL show a favorable association.

THCA, UCEC, and LGG are the cancer types where ZNF295-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Quartile	All	0.839	1.000	<.001	78	view →
UCEC	OS	Median	All	0.957	0.895	<.001	52	view →
LGG	DFS	Median	All	0.665	0.802	<.001	52	view →
ACC	DFS	Tertile	All	0.444	0.831	<.001	43	view →
BRCA	OS	Median	IV	0.334	0.769	.001	39	view →
KIRC	OS	Quartile	II,III,IV	0.753	0.863	.007	39	view →
CHOL	OS	Quartile	All	0.829	0.137	.001	37	view →
KICH	DFS	Tertile	II,III,IV	0.496	1.000	.006	35	view →
LUAD	OS	Median	III,IV	0.427	0.200	.011	31	view →
UVM	DFS	Median	III,IV	0.197	0.682	.004	25	view →
UCS	OS	Tertile	IV	0.883	0.224	.024	24	view →
MESO	OS	Quartile	II,III,IV	0.700	0.228	.006	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZNF295-AS1–THCA (OS)

Open the THCA breakdown →