ZNF286B

Across TCGA pan-cancer cohorts, ZNF286B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF286B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF286B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF286B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and THCA are the cancer types where ZNF286B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF286B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.291	<.001	10	view →
KICH	Male	All	−0.650	<.001	8	view →
THCA	Male	All	−0.375	<.001	7	view →
KIRC	All	II,III,IV	−0.192	<.001	6	view →
LUSC	All	All	+0.366	<.001	5	view →
LIHC	Female	II,III,IV	+0.183	<.001	5	view →
CHOL	Male	All	+0.858	<.001	3	view →
BLCA	Female	All	+0.467	.036	3	view →
ESCA	Female	All	+0.363	.002	2	view →
PAAD	Female	All	−0.240	.001	2	view →
LUAD	Female	II,III,IV	−0.178	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF286B–HNSC

Open the HNSC breakdown →