ZNF285B

Across TCGA pan-cancer cohorts, ZNF285B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ZNF285B data layer.

The strongest signal is observed in mesothelioma (MESO), where higher ZNF285B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF285B expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

MESO, HNSC, and LGG are the cancer types where ZNF285B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.279	0.545	<.001	111	view →
HNSC	DFS	Quartile	IV	0.566	0.274	.002	56	view →
LGG	OS	Median	All	0.752	0.869	<.001	53	view →
SKCM	OS	Quartile	III,IV	0.578	0.329	.010	26	view →
LUSC	DFS	Median	III,IV	0.509	0.916	.006	22	view →
GBM	OS	Median	All	0.561	0.262	<.001	21	view →
KIRC	DFS	Tertile	All	0.867	0.680	<.001	21	view →
COAD	DFS	Quartile	II,III,IV	0.876	0.636	.004	18	view →
READ	OS	Median	All	0.824	0.473	.005	17	view →
OV	DFS	Quartile	IV	0.587	0.352	.042	12	view →
KICH	DFS	Median	All	0.717	0.946	.011	9	view →
ACC	DFS	Median	III,IV	0.803	0.382	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ZNF285B–MESO (DFS)

Open the MESO breakdown →