ZNF285

Across TCGA patient cohorts, ZNF285 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF285-associated genes across cancer lineages are c-Met_pY1235, MEK1, and C-Raf. Each is linked with ZNF285 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF285-to-partner and partner-to-ZNF285 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by ZNF285-low versus ZNF285-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF285→partner) and Y-score (partner→ZNF285) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.080	+2.247	.003	.001	3	3
UCEC	MEK1 →	+0.361	+1.847	.007	.008	3	2
UCEC	C-Raf →	+0.148	+1.502	.005	.030	3	2
SKCM	AMPK_alpha →	+0.139	+2.000	.011	.009	3	1
SKCM	CDK1 →	+0.309	+2.000	<.001	.029	3	1
UCEC	EGFR_pY1068 →	-0.274	-1.847	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

c-Met_pY1235 by ZNF285 expression — UCEC

Explore this box plot interactively →