Across TCGA pan-cancer cohorts, ZNF284 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ZNF284 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF284 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF284 expression acts as an unfavorable survival marker.

HNSC, LUAD, and BRCA are the cancer types where ZNF284 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.059	0.712	<.001	30	view →
LUAD	OS	Median	II,III,IV	0.004	0.751	<.001	20	view →
BRCA	OS	Median	All	0.111	0.578	.013	18	view →
COAD	OS	Median	All	0.123	0.803	<.001	18	view →
CESC	DFS	Median	II,III,IV	0.193	0.705	.045	6	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	DFS	Median	II,III,IV	0.091	0.427	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

Exploration

Same gene, other analysis: ZNF284 tumor-vs-normal RNA expression · all ZNF284 data types