Across TCGA patient cohorts, ZNF284 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF284-associated genes across cancer lineages are p27, PKC-delta_pS664, and Shc_pY317. Each is linked with ZNF284 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF284-to-partner and partner-to-ZNF284 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF284→partner) and Y-score (partner→ZNF284) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27 →	-0.252	-2.906	.006	.001	3	2
UCEC	PKC-delta_pS664 →	-0.102	-2.999	.044	.035	3	2
UCEC	Shc_pY317 →	-0.260	-3.321	<.001	.010	3	2
UCEC	eEF2 →	+0.381	+1.700	.012	.044	3	1
UCEC	EGFR_pY1068 →	-0.400	-3.906	<.001	<.001	3	1
UCEC	eIF4E →	+0.179	+2.222	.046	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

ZNF284 survival (RNA) · tumor vs normal (RNA) · all ZNF284 data types