ZNF282

Across TCGA patient cohorts, ZNF282 mutation is significantly associated with the RNA expression of many other genes, with 1,707 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF282-associated genes across cancer lineages are ORC5, SMIM4, and LETM1. Each is linked with ZNF282 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF282-to-partner and partner-to-ZNF282 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ORC5 grouped by ZNF282-low versus ZNF282-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF282→partner) and Y-score (partner→ZNF282) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ORC5 →	+0.360	+1.925	.005	.005	3	2
UCEC	SMIM4 →	+0.472	+3.775	<.001	<.001	3	2
UCEC	LETM1 →	+0.440	+2.338	<.001	.003	3	2
UCEC	MAMDC4 →	+0.519	+2.321	.004	.001	3	2
UCEC	ANAPC5 →	+0.285	+2.343	.007	<.001	3	2
UCEC	GOLGA3 →	+0.475	+3.071	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,707 associations by consensus.

ORC5 by ZNF282 expression — UCEC

Explore this box plot interactively →