ZNF282

Across TCGA cell cohorts, ZNF282 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,071 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ZNF282-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Positive regulation of isotype switching to IgG isotypes, and Regulation of transcription initiation by RNA polymerase II. Each is linked with ZNF282 in more than 17 cancer types. Because this analysis shows association rather than direction, both ZNF282-to-partner and partner-to-ZNF282 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by ZNF282-low versus ZNF282-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF282→partner) and Y-score (partner→ZNF282) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pre-mRNA catabolic process →	+0.183	+0.728	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.165	+0.784	.003	.001	3	14
LARGE_INTESTINE	Regulation of transcription initiation by RNA polymerase II →	+0.056	+0.906	<.001	<.001	3	14
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.134	+0.806	<.001	<.001	3	13
BLOOD_Lymphoma	Positive regulation of DNA recombination →	+0.062	+0.839	<.001	<.001	3	13
BONE	RNA export from nucleus →	+0.108	+0.721	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,071 associations by consensus.

Pre-mRNA catabolic process by ZNF282 expression — BONE

Explore this box plot interactively →