ZNF282

Across TCGA cell cohorts, ZNF282 mutation is significantly associated with the RNA expression of many other genes, with 536 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF282-associated genes across cancer lineages are GUCA2A, PES1, and ANKRD54. Each is linked with ZNF282 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF282-to-partner and partner-to-ZNF282 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by ZNF282-low versus ZNF282-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF282→partner) and Y-score (partner→ZNF282) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	2
LARGE_INTESTINE	PES1 →	+0.483	+3.537	.009	.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.581	+3.451	<.001	.002	3	1
LARGE_INTESTINE	TMED8 →	+0.515	+3.364	.008	.002	3	1
LARGE_INTESTINE	CEP192 →	+0.750	+3.364	<.001	.002	3	1
LARGE_INTESTINE	MED26 →	+0.362	+3.067	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 536 associations by consensus.

GUCA2A by ZNF282 expression — BLOOD_Leukemia

Explore this box plot interactively →