ZNF281

Across TCGA pan-cancer cohorts, ZNF281 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ZNF281’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF281 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF281 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where ZNF281 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF281 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.724	<.001	12	view →
LSCC	Female	All	+0.735	<.001	9	view →
LUAD	Female	All	+0.390	<.001	9	view →
CCRCC	Male	All	+0.225	<.001	8	view →
COAD	Male	II,III,IV	−0.681	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ZNF281–HNSC

Open the HNSC breakdown →