ZNF281

Across TCGA patient cohorts, ZNF281 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,764 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ZNF281-associated proteins across cancer lineages are ZNF281_T888, CEP170, and IPO9. Each is linked with ZNF281 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZNF281-to-partner and partner-to-ZNF281 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF281 versus ZNF281_T888 in BRCA, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF281→partner) and Y-score (partner→ZNF281) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF281_T888 →	+0.583	+0.765	<.001	<.001	3	6
LSCC	CEP170 →	+0.357	+0.670	<.001	<.001	3	6
UCEC	IPO9 →	+0.323	+0.544	<.001	<.001	3	5
PDAC	LOXL2 →	+0.708	+0.472	<.001	<.001	3	5
LUAD	NAV1_S142 →	+1.284	+0.484	<.001	<.001	3	5
OV	DBN1 →	+0.600	+0.325	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,764 associations by consensus.

ZNF281 vs ZNF281_T888 — BRCA

Explore this scatter interactively →