ZNF281

Across TCGA patient cohorts, ZNF281 protein abundance is significantly associated with the RNA expression of many other genes, with 7,816 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF281-associated genes across cancer lineages are NEK2, UBE2T, and KIF14. Each is linked with ZNF281 in more than 6 cancer types. Because this analysis shows association rather than direction, both ZNF281-to-partner and partner-to-ZNF281 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF281 versus NEK2 in UCEC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF281→partner) and Y-score (partner→ZNF281) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NEK2 →	+1.217	+0.264	<.001	.003	3	7
UCEC	UBE2T →	+0.999	+0.202	<.001	<.001	3	7
OV	KIF14 →	+0.926	+0.275	<.001	<.001	3	6
OV	BUB1 →	+1.092	+0.379	<.001	<.001	3	6
OV	ASPM →	+1.140	+0.447	<.001	<.001	3	6
OV	MYBL2 →	+1.855	+0.470	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,816 associations by consensus.

ZNF281 vs NEK2 — UCEC

Explore this scatter interactively →