ZNF281

Across TCGA patient cohorts, ZNF281 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF281-associated genes across cancer lineages are ATM, Bad_pS112, and eIF4E. Each is linked with ZNF281 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF281-to-partner and partner-to-ZNF281 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF281-low versus ZNF281-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF281→partner) and Y-score (partner→ZNF281) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.505	-2.991	.012	.036	3	2
COAD	Bad_pS112 →	-0.224	-2.991	.028	.036	3	2
UCEC	eIF4E →	+0.177	+2.598	.008	.005	3	2
UCEC	Lck →	+0.211	+1.523	<.001	.008	3	2
UCEC	MEK1 →	+0.438	+2.058	<.001	<.001	3	2
UCEC	MSH6 →	-0.278	-2.115	.008	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ATM by ZNF281 expression — COAD

Explore this box plot interactively →