ZNF281

Across TCGA cell cohorts, ZNF281 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,647 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF281-associated GO terms across cancer lineages are Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery, Establishment of RNA localization, and Nucleic acid transport. Each is linked with ZNF281 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF281-to-partner and partner-to-ZNF281 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery grouped by ZNF281-low versus ZNF281-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF281→partner) and Y-score (partner→ZNF281) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.140	+0.969	<.001	.001	3	15
STOMACH	Establishment of RNA localization →	+0.091	+0.836	.001	.002	3	15
STOMACH	Nucleic acid transport →	+0.094	+0.832	<.001	.002	3	14
STOMACH	RNA transport →	+0.094	+0.832	<.001	.002	3	14
SOFT_TISSUE	RNA localization →	+0.089	+0.732	<.001	.002	3	14
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to endoplasmic reticulum membrane →	+0.098	+0.874	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,647 associations by consensus.

Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery by ZNF281 expression — STOMACH

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