ZNF280A

Across TCGA patient cohorts, ZNF280A mutation is significantly associated with the RNA expression of many other genes, with 1,527 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF280A-associated genes across cancer lineages are TUBB8P5, ERICD, and MTATP6P21. Each is linked with ZNF280A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF280A-to-partner and partner-to-ZNF280A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB8P5 grouped by ZNF280A-low versus ZNF280A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280A→partner) and Y-score (partner→ZNF280A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBB8P5 →	+0.436	+1.689	<.001	.008	3	2
LUSC	ERICD →	+0.462	+3.584	.004	.003	3	2
UCEC	MTATP6P21 →	+0.254	+1.967	<.001	.005	3	2
COAD	MTCO2P23 →	+0.235	+4.136	<.001	.008	3	2
HNSC	RNA5SP211 →	+0.179	+4.221	<.001	.008	3	2
UCEC	UQCR10 →	+0.365	+2.098	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,527 associations by consensus.

TUBB8P5 by ZNF280A expression — UCEC

Explore this box plot interactively →